- Alt-click is your friend: objects hidden underneath things are fully interactive by using alt + click. Whether welding a vent under a table, making a hidden wall underneath a poster, or sorting through a pile of equipment, you can use this to save time.
Boxes in bags: if your box is in your pack, you can still add items to it without having it in your hand.
Are they worth cloning: examine a corpse to see if their soul has departed. If not, you got a buddy looking for cloning!
Unhug yourself: if you're quick enough, you can click on the hugger on your face in your equipment slot to take it off (though you'll still be knocked unconscious.)
Extra knife: put a knife in your teeth by sticking it in your mask slot.
Macros, macros, macros: the wiki page has a guide to using macros. If you're play a Sentinel, Spitter, Praetorian, or Carrier, this is essential!
Don't evolve: Praetorians and Ravagers have drawbacks compared to their pre-evolved cousins. Spitters can use vents and have a significantly higher plasma regen, so only evolve into a Praetorian in siege situations. Ravagers are rarely useful, outside of extra damage/health, so be robust and stick with a warrior.
One-two punch: If you're a runner or warrior, carry a facehugger in both hands. Pounce your target, use one hugger to remove the helmet, then ctrl + x to switch hands and slap them again! Bam, facehugged!
No pocket flashlights: flashlights can be added to any gun, including pistols, so instead of putting flashlights into your pockets, put them on a pistol and put those in your pockets.
Infinite lasers: so you're the Commander and aliens have breached Sulaco? Wrench a charger and pull it behind you to recharge your laser gun.
Cigarettes: lighters can be put in your cigarette pack to save space, or, alternatively, use a welding tool like a badass.
Escaping the nest: you can resist against nesting even while unconscious.
Pre-vent crawl: if you plan on sticking around the area,alt + click the vent you plan to crawl through and hover your location to the preferred destination. If you gotta get out of there fast, you can pull up the menu and get there in just one click.
Useful guides! (More will be added.)
Mr. Penguin's Guide to Bullet Paths http://cm-ss13.com/viewtopic.php?f=94&t=1954
My Guide on Playing a Survivor http://cm-ss13.com/viewtopic.php?f=94&t=2341
Gromoi's Guide to Surgery http://cm-ss13.com/viewtopic.php?f=94&t=2180
Added via comments:
Butterrobber202: Pro-tip: Never forget your Gun (( This happens more than you think.... ))
Evilkyle24: When hunting as an alien, turn off night vision. This lets you see the range of the human's vision, and any active light sources! You can see them before they're even on the screen!
Dragon2323: 1: As a marine, you are the Corps' equivalent to some blood-red meat if you stray far from the other Marines. Medics are best on center formation behind the Squad Leader, Engineers on side formations behind the Standards.
2: Tramadol and Anti-toxin pills are the best thing to put in your armour as a medic.
3: Never lose your standard issue Tramadol pill from your survival box. That is the line between numb, painless life for a few minutes, and imminent death.
4: If you utilize the M37 shotgun, bind pump-shotgun to a key within reach. If you play on hotkeys, which movement is WASD due to, I'd suggest F or G.
5. Touching the L6 SAW is an equal act to killing yourself. Damage overtakes firerate, it's better as a semi-automatic rifle.
6. Drones, for the love of God, stay away from Marines with toolboxes.
7. Also stay away from Marines with M4A3 handguns and knives.
8. Spitters, keep in mind that you have a toggle for quick-spitting which will get in the way of hotkey examines.
9. If you have a handful of Marines around you after another has been hugged, do not waste time pulling them back. Pulling them back can allow the to-infect timer to count down even further, and you may lose a Marine for the next fight(s), depending on if they know what's coming, or if they have to go to the Sulaco.
10. ... Don't play Sulaco Medic if you don't know how to do surgery. Don't even fullstrip as a surgeon. Your waste of time will take players out of the round, especially if they got there as soon as the heavier symptoms of infection set in. Keep in mind that Sulaco Medics are usually all-purpose medical practitioners.